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IACUC Member Refresher Case Studies

This course provides retraining for IACUC members using case studies.

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About this Course


This refresher course presents learners with various scenarios depicting real-life problems encountered by IACUCs; the scenarios typically present both sides of contentious issues. Learners (IACUC members) are then asked to select actions that the IACUC or investigator could take. This approach to refresher training is intended to form an interesting re-encounter of issues for the learner. A suggested refresher course consists of three or more completed case studies. The case studies can also be used during IACUC meetings for supplemental on-site training purposes.

Language Availability: English

Suggested Audiences: IACUC Members, Investigators


Course Content



ACU Program Basics


Toggle Content IACUC Composition

Pertains to the requirements and qualifications of a duly constituted IACUC.

Recommended Use: Elective
ID (Language): 15508 (English)
Author(s): Michael D. Mann, PhD - University of Nebraska Medical Center (retired)

Toggle Content Qualifications of Personnel Managing Analgesics

Pertains to an IACUC’s evaluation of training methods to assure that persons working with animals are sufficiently trained and qualified prior to working with animals.

Recommended Use: Elective
ID (Language): 15518 (English)
Author(s): Jennifer Kalishman, DVM, MS - Washington University School of Medicine

Toggle Content Occupational Health

Discusses the requirements for an occupational health and safety program.

Recommended Use: Elective
ID (Language): 15526 (English)
Author(s): Randall Nelson, PhD - University of Tennessee Health Science Center

Toggle Content Managing SOPs

Highlights the appropriate management of standard operating procedures (SOPs).

Recommended Use: Elective
ID (Language): 15530 (English)
Author(s): Michael D. Mann, PhD - University of Nebraska Medical Center (retired)

Toggle Content Disaster Planning

Shows the development and maintenance of an animal facility disaster plan.

Recommended Use: Elective
ID (Language): 15523 (English)
Author(s): Kathy Wadsworth, CPIA, CIP - CITI Program; Susan M. Miller MD, MPH - Houston Methodist

Toggle Content USDA Pain Classification

Discusses the application of the USDA pain classifications.

Recommended Use: Elective
ID (Language): 15519 (English)
Author(s): Jennifer Kalishman, DVM, MS - Washington University School of Medicine

Toggle Content The Institutional Official’s (IO’s) Role and Authority Limits

Covers the role and authority of the IO with regard to animal research oversight.

Recommended Use: Elective
ID (Language): 17002 (English)
Author(s): Ernest D. Prentice, PhD - University of Nebraska Medical Center; M. Elizabeth Blackburn, CPIA - University of Nebraska Medical Center


Investigating Noncompliance


Toggle Content Tackling Investigator Noncompliance

Involves IACUC investigation into unapproved activities.

Recommended Use: Elective
ID (Language): 15514 (English)
Author(s): Tom Zimmerman, DVM, MPVM, DACLAM - Stony Brook University, New York

Toggle Content Investigating Allegations of Noncompliance, Whistle-blower Protection, and Due Process

Involves IACUC review of an allegation of noncompliance, whistle-blower protections, and appropriate due-process.

Recommended Use: Elective
ID (Language): 15522 (English)
Author(s): Kathy Wadsworth, CPIA, CIP - CITI Program

Toggle Content Investigations of Noncompliance

Involves IACUC review of an allegation of noncompliance and appropriate due-process.

Recommended Use: Elective
ID (Language): 14948 (English)
Author(s): Paul Braunschweiger, PhD - CITI Program

Toggle Content Unapproved Intervention

Discusses the potential consequences of conducting unapproved procedures in animals.

Recommended Use: Elective
ID (Language): 15527 (English)
Author(s): Randall Nelson, PhD - University of Tennessee Health Science Center

Toggle Content No Harm, No Foul

Discusses IACUC review of noncompliance and protocol review.

Recommended Use: Elective
ID (Language): 17058 (English)
Author(s): Randall J. Nelson, PhD - The University of Tennessee Health Science Center; Cynthia S. Gillett, DVM, DACLAM, CPIA - University of Minnesota (Retired)

Toggle Content Shared Institutional Goals of Animal Health and Welfare

Discusses appropriate IACUC processes for review and reporting of potential noncompliance.

Recommended Use: Elective
ID (Language): 17059 (English)
Author(s): Jennifer Kalishman, DVM - Washington University School of Medicine


Postapproval Monitoring


Toggle Content Semiannual Facility Inspections

Highlights the regulatory requirements for semi-annual facility inspections.

Recommended Use: Elective
ID (Language): 15515 (English)
Author(s): Cynthia S. Gillett, DVM, DACLAM, CPIA - University of Minnesota (Retired)

Toggle Content Managing Animals after Protocol Expiration

Reviews IACUC timelines for review of animal activities and the proper management of animals following a lapse in IACUC approval.

Recommended Use: Elective
ID (Language): 15517 (English)
Author(s): Cynthia S. Gillett, DVM, DACLAM, CPIA - University of Minnesota (Retired)

Toggle Content Lab Inspection/Compliance

Discusses lab inspection and compliance issues.

Recommended Use: Elective
ID (Language): 15521 (English)
Author(s): Michael Mann, PhD - University of Nebraska Medical Center (retired)

Toggle Content Trust, But Verify

Highlights post-approval review of use of expired medications and subsequent use of data for publication.

Recommended Use: Elective
ID (Language): 17000 (English)
Author(s): Randall J. Nelson, PhD - The University of Tennessee Health Science Center


Protocol Review Issues


Toggle Content Protocol Amendments and Modifications

Discusses differences between protocol amendments, modifications, and veterinary intervention for animal welfare.

Recommended Use: Elective
ID (Language): 15516 (English)
Author(s): Kathy Wadsworth, CPIA, CIP - CITI Program

Toggle Content Grant Reviews

Highlights grant review issues.

Recommended Use: Elective
ID (Language): 15520 (English)
Author(s): Michael Mann, Ph.D. - University of Nebraska Medical Center (retired)

Toggle Content Inter-related Protocols

Involves review of potential noncompliance, and Office of Laboratory Animal Welfare (OLAW) and Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) reporting requirements.

Recommended Use: Elective
ID (Language): 15524 (English)
Author(s): Gwenn S.F. Oki, MPH - City of Hope Medical Center

Toggle Content Protocol Approval Expiration

Discusses the requirement for regular IACUC review of animal activities and possible options and consequences in the event of a lapse in approval.

Recommended Use: Elective
ID (Language): 15528 (English)
Author(s): Ernest Prentice, PhD - University of Nebraska Medical Center

Toggle Content Use of Ad Hoc Consultants in Protocol Review/Confidentiality Issues

Describes the appropriate use of ad hoc consultants in IACUC review of animal activities.

Recommended Use: Elective
ID (Language): 15529 (English)
Author(s): Ernest Prentice, PhD - University of Nebraska Medical Center

Toggle Content Using the Veterinary Verification & Consultation (VVC) Process for Review of Select Significant Changes – “XYZ Therapeutics”

Highlights the appropriate use of the Veterinarian Verification and Consultation (VVC) process in the review of significant changes at “XYZ Therapeutics.”

Recommended Use: Elective
ID (Language): 16998 (English)
Author(s): Cynthia S. Gillett, DVM, DACLAM, CPIA - University of Minnesota (Retired)

Toggle Content Using the Veterinary Verification & Consultation (VVC) Process for Review of Select Significant Changes – “Great Eastern University”

Discusses the appropriate use of the Veterinarian Verification and Consultation (VVC) process in the review of significant changes at “Great Eastern University.”

Recommended Use: Elective
ID (Language): 16997 (English)
Author(s): Jerry Collins - Yale University; Cynthia S. Gillett, DVM, DACLAM, CPIA - University of Minnesota (Retired)

Toggle Content Reporting and Euthanasia with Wildlife

Covers IACUC review and approval of wildlife research and appropriate methods of euthanasia in the field. The case study also discusses reporting requirements for wildlife research.

Recommended Use: Elective
ID (Language): 16999 (English)
Author(s): Robert S. Sikes, Ph.D - University of Arkansas at Little Rock

Toggle Content Measuring Pain

Discusses IACUC review of pain research and sex bias in animal models.

Recommended Use: Elective
ID (Language): 17001 (English)
Author(s): Michael D. Mann, PhD - University of Nebraska Medical Center (retired)

Toggle Content Establishing a New Animal Model

Describes IACUC review and training requirements for the use of new animal research models to study human disease.

Recommended Use: Elective
ID (Language): 17003 (English)
Author(s): Kathy Wadsworth, CPIA, CIP - CITI Program

Toggle Content Rationale for New Model Development

Discusses IACUC review and appropriate justification for the use of new animal research models.

Recommended Use: Elective
ID (Language): 17004 (English)
Author(s): Kathy Wadsworth, CPIA, CIP - CITI Program