3Rs Certificate Course

This module takes you on a journey from the first presentation of the 3Rs principles in 1957 to the modern organizations using and championing these principles. In between, you will learn to clearly define the 3Rs and their relevance to a culture of care. Finally, you will learn to identify key examples of the 3Rs and helpful resources to their application.

Recommended Use: Required
ID (Language): 21587 (English)
Author(s): Natalie Bratcher-Petersen, MS - Digital In Vivo Alliance/ TLR Ventures; Sylvie Cloutier, PhD - Canadian Council on Animal Care; Brianna Gaskill, PhD - Novartis Biomedical Research; Megan LaFollette, MS, PhD - The 3Rs Collaborative; Elizabeth Nunamaker, DVM, PhD, MS, DACLAM, DACAW - The 3Rs Collaborative; Sally Thompson-Iritani, DVM, PhD, CPIA, CHABP, CCFP, CFE - University of Washington; Erin Vogelsong, MS, CMAR, LATG - Drexel University; Lauren Young, MSc - The 3Rs Collaborative

This module aims to provide a broad understanding of modern interpretations of replacement, current strategies for replacement, advantages and challenges of replacements (especially compared to animal models), and future directions and case studies for implementation. The module includes high-level overviews of in vitro, in chemico, in silico, and physical replacements for traditional animal techniques. New replacements and improvements to current replacements are continuously being developed, so you are encouraged to conduct additional research into replacement options for whatever specific area of animal research you are currently involved with. A list of resources to learn more about replacement strategies can be found at the end of the module.

Recommended Use: Required
ID (Language): 21588 (English)
Author(s): Natalie Bratcher-Petersen, MS - Digital In Vivo Alliance/ TLR Ventures; Sylvie Cloutier, PhD - Canadian Council on Animal Care; Brianna Gaskill, PhD - Novartis Biomedical Research; Megan LaFollette, MS, PhD - The 3Rs Collaborative; Elizabeth Nunamaker, DVM, PhD, MS, DACLAM, DACAW - The 3Rs Collaborative; Sally Thompson-Iritani, DVM, PhD, CPIA, CHABP, CCFP, CFE - University of Washington; Erin Vogelsong, MS, CMAR, LATG - Drexel University; Lauren Young, MSc - The 3Rs Collaborative

This module deepens your understanding of the 3Rs principle of reduction. You will begin by learning about the core principles of reduction, which involves reducing the number of animals required throughout an experimental timeline via careful experimental design, measurement selection, and data analysis. You will also learn how sources of intrinsic and extrinsic variation can affect variability and reproducibility. Finally, you will learn about applying reduction in animal colony management in making decisions about purchasing, breeding, or repurposing animals.

Recommended Use: Required
ID (Language): 21589 (English)
Author(s): Natalie Bratcher-Petersen, MS - Digital In Vivo Alliance/ TLR Ventures; Sylvie Cloutier, PhD - Canadian Council on Animal Care; Brianna Gaskill, PhD - Novartis Biomedical Research; Megan LaFollette, MS, PhD - The 3Rs Collaborative; Elizabeth Nunamaker, DVM, PhD, MS, DACLAM, DACAW - The 3Rs Collaborative; Sally Thompson-Iritani, DVM, PhD, CPIA, CHABP, CCFP, CFE - University of Washington; Erin Vogelsong, MS, CMAR, LATG - Drexel University; Lauren Young, MSc - The 3Rs Collaborative

Once it has been determined that no suitable replacements exist and after reduction has been applied to ensure robust experimental design, any animals that are used in experimental research should have their lives “refined.” This module will expand your understanding of the 3Rs principle of refinement. You will begin by learning definitions and models of welfare and how these apply to refinement. Then, you will learn how each individual working in an animal research facility should enact refinement depending on their role. You will learn the importance of providing each animal with a species-specific enriched environment and review several examples of ways that housing, husbandry, handling, and experimental procedures can be refined. Finally, you will be introduced to concepts related to harm, benefits, and suffering as well as classification systems and endpoints.

Recommended Use: Required
ID (Language): 21590 (English)
Author(s): Natalie Bratcher-Petersen, MS - Digital In Vivo Alliance/ TLR Ventures; Sylvie Cloutier, PhD - Canadian Council on Animal Care; Brianna Gaskill, PhD - Novartis Biomedical Research; Megan LaFollette, MS, PhD - The 3Rs Collaborative; Elizabeth Nunamaker, DVM, PhD, MS, DACLAM, DACAW - The 3Rs Collaborative; Sally Thompson-Iritani, DVM, PhD, CPIA, CHABP, CCFP, CFE - University of Washington; Erin Vogelsong, MS, CMAR, LATG - Drexel University; Lauren Young, MSc - The 3Rs Collaborative

This module aims to encourage and guide your practical daily application of the 3Rs principles using a series of scenarios and exercises. Additionally, this module introduces key topics closely related to the 3Rs such as a culture of care, openness/transparency, and the connection between human and animal well-being.

Recommended Use: Required
ID (Language): 21591 (English)
Author(s): Natalie Bratcher-Petersen, MS - Digital In Vivo Alliance/ TLR Ventures; Sylvie Cloutier, PhD - Canadian Council on Animal Care; Brianna Gaskill, PhD - Novartis Biomedical Research; Megan LaFollette, MS, PhD - The 3Rs Collaborative; Elizabeth Nunamaker, DVM, PhD, MS, DACLAM, DACAW - The 3Rs Collaborative; Sally Thompson-Iritani, DVM, PhD, CPIA, CHABP, CCFP, CFE - University of Washington; Erin Vogelsong, MS, CMAR, LATG - Drexel University; Lauren Young, MSc - The 3Rs Collaborative