Never-Ending Acronym Madness: NAMs & Animal Research

Analyzes inconsistent use of “NAMs,” offers a harmonized definition, and shows how to apply it while distinguishing it from related concepts like the 3Rs and identifying out-of-scope technologies.

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About this Webinar

The acronym “NAMs” is used inconsistently across scientific and regulatory communities, contributing to confusion and misaligned expectations. This webinar examines the evolving landscape of NAMs definitions and introduces a proposed harmonized, goal-oriented definition applicable to chemicals, pharmaceuticals, and basic research.

Participants will explore how this harmonized definition can be applied to determine whether specific technologies qualify as NAMs, and how these approaches relate to—but remain distinct from—the 3Rs principles. The webinar will also introduce the concept of Refinement-Enabling Innovations (REIs) and examine categories of technologies that fall outside the proposed NAMs framework, including traditional in vivo models and certain refinement techniques.

Release Date: July 23, 2026

Language Availability: English

Suggested Audiences: IACUC Members, Investigators, Research Administrators, Scientists, Students, Technicians, Veterinarians

Organizational Subscription Price: Included as part of an annual subscription to our All Access Webinar Package


Webinar Content

Never-Ending Acronym Madness: NAMs & Animal Research

Presented by: Megan R. LaFollette, MS, PhD – The 3Rs Collaborative

Learning Objectives:

  • Describe the landscape of existing NAMs definitions and how inconsistent use of the acronym across regulatory agencies and scientific sectors creates communication challenges.
  • Apply the proposed harmonized NAMs definition to evaluate whether a given technology qualifies as a NAM across different research and regulatory contexts.
  • Distinguish NAMs from related concepts, including the 3Rs principles of Replacement, Reduction, and Refinement, and the newly proposed category of Refinement-Enabling Innovations (REIs).
  • Examine technologies that fall outside the proposed NAMs definition — such as whole live invertebrate animal models, traditional in vivo research, and refinement techniques — and the rationale for their exclusion.

Recommended Use: Required
ID (Language): 21248 (English)


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